The 34-year-old will appear at Belfast Magistrates Court later this morning for a first remand hearing.
Police were called to a house in Titania Street off the Cregagh Road just after midnight on Sunday.
The Ambulance Service said the victim was treated at the scene for stab wounds.
He was taken to the Royal Victoria Hospital, where he died a short time later.
A 34-year-old man and a 30-year-old man were later arrested by police on suspicion of murder.
The 30-year-old has been released unconditionally.