He has been charged with four counts of murder and one count of arson with intent to endanger life.
He is due to appear at Enniskillen Magistrates Court on Monday morning.
Four people died in the fire including a young child at the premises on Molly Road, Derrylin, Co Fermanagh.
The landlord of the house said they were Crystal Gossett, her son Edward (16) and her daughter Diane (19).
The name of the young child, believed to be 18-months old, is not yet known.