The collision on the Templepatrick Road near Ballyclare occurred at around 6.10 am this morning close to a local service station.
One of the injured males is believed to have sustained serious injuries however these are not believed to be life threatening at present.
Inspector Colin Ash is appealing for witnesses to the collision to get in touch with police. Please call 101, quoting reference number 268 03/03/18.
The Templepatrick Road remains closed at present.