Karen was last seen in the east Belfast area around 10am on Thursday 23 October.
She is described as being 5’1” tall, of slim build and long dark curly hair tied up in a bun.
Karen speaks with a South African accent.
When last seen she was wearing a pink jersey, black leggings, a large grey coat and pink glitter slippers.
Police are appealing for Karen, or anyone who knows of her whereabouts, to contact officers on 101 quoting reference 447 24/10/17.