The man was behind the wheel of a red Renault Clio involved in a crash with a white Volkswagen Passat at Cotton Road in Bangor.
The collision was close to the junction at Six Road Ends.
Police appealing for any witnesses who may have seen the collision.
Anyone with any information regarding the incident is asked to call the non-emergency number 101, using reference number 390/21/2/2017.
The road remains closed while the scene is examined.