A suspicious object – a possible pipe bomb style device – has been found in Rosapenna Street.
Police are at the scene and Army Technical Officers are also at the scene examining the device.
The street is closed at its junction with Rosapenna Court.
Oldpark Road between Glenview Street and Hillview Road is also closed.
Diversions are in place.
Cliftonville Community Centre on Manor Street has been made available for evacuated people.
Sinn Féin MLA Gerry Kelly has condemned those responsible for a security alert in the Oldpark area of north Belfast.
Mr Kelly said: “This security alert following the discovery of a suspicious object at the junction of Rosapenna Street and Oldpark has brought nothing but disruption to the area.
“A number of businesses have had to be evacuated while the device is examined.
“Incidents like this serve no purpose whatsoever and need to stop immediately.
“Hopefully the area can get back to normal soon so that everyone can get on with their lives free from disruption.”