The crash happened on the Manoo Road in Kesh, Co Fermanagh,at about 6 pm last night, Wednesday, June 10.
Police say a woman also injured in the accident in the single vehicle crash.
She is described as being in a stable condition in the hospital.
The man who died is said to be in his 50s.
As yet, police have not yet released his name until all family members have been informed.
The PSNI in Enniskillen want anyone who witnessed the crash to contact them on the 101 non-emergency number.