The males, both aged 23, have been charged are in connection with seven burglaries, six at commercial premises and one at a property, in the Comber, Dromara, Hillsborough and Dundrum areas on January 5th.
One of the 23-year-old males is also charged with possession of Class B and Class C drugs.
A third 23-year-old male who was also charged in connection with the burglaries will appear at Downpatrick Magistrates Court later this month.
Detectives would continue to appeal to anyone with information in relation to any of the burglaries to contact them at Downpatrick police station on the non-emergency number 101. Alternatively, information about crime can be passed to the Crimestoppers charity anonymously on 0800 555 111.