It brings to 62 the number of people killed on the province’s roads this year.
The accident happened just before 8.30 pm on Saturday night on the Ballywalter to Greyabbey Road in Co Down.
Four other men who were in the van have been taken to hospital.
However, their injuries are not believed to be life-threatening.
The road remains closed as the PSNI’s Collision Investigation examine the scene of the crash.