From next year customer can travel to Prague, Rome, Gran Canaria and Zante on the Greek Islands.
Jet2 said the jobs would include flight and cabin crew, as well as engineers and ground operations staff.
A third dedicated aircraft will come to Belfast and said next year will be its “biggest-ever flying programme” from the international.
It will run more than 70 flights a week to 16 destinations.
Uel Hoey, business development manager at the airport, said: “The decision to base a third aircraft here reinforces the airline’s belief in the Northern Ireland market.”
Rome and Prague will be served by twice weekly flights.
The other new routes will see one flight a week.