It follows a two vehicle road traffic collision involving a lorry and a car on the M1 motorway near Dungannon this evening.
The collision occurred on the eastbound carriageway at around 5.10 pm.
The motorway is expected to remain closed in both directions for some time whilst police enquiries are carried out.
Inspector Andrew Archibald has appealed for anyone who witnessed the collision to contact police in Dungannon on 101.
The victim is the 21st person to have died on the province’s roads this year – on average four deaths a month since January 1.