He was driving his car when it was in collision with a lorry at the McKinstry Road in Dunmurry on Friday morning.
It is understood that a female passenger and the lorry driver were treated in the Royal Victoria Hospital in west Belfast.
The road remains closed in both directions between Queensway and Wilmar Road.
A probe has been launched by the PSNI’s Collision Investigation Unit.
Anyone who witnessed the crash is asked to ring police 0n 0845 600 8000.